Abstract
A series of platinum(II) tri- n-butylphosphine complexes having the formulas cis-[PtCl 2L 2], NEt 4PtCl 3L], [PtCl(en)L]Cl, [Pt(en)L 2](ClO 4) 2, sym-trans-[Pt 2Cl 4L 2], [Pt 2Cl 2L 4](ClO 4) 2, trans,trans-[PtCl 2L(μ-N 2H 4)PtCl 2L] trans,trans-[PtCl 2L(μ-en)PtCl 2L], and cis,cis-[PtClL 2(μ-N 2H 4)PtClL 2](ClO 4) 2 (L = tri- n-butylphosphine; en = ethylenediamine) have been synthesized and their cytotoxic activity in vitro and in vivo has been studied. The solution behavior of the novel dinuclear diamine-bridged platinum(II) complexes has been investigated by means of UV and 31P NMR spectroscopy. For the ionic hydrazine compound cis,cis-[PtClL 2(μ-N 2H 4)PtClL 2](ClO 4) 2, an x-ray structure determination is reported. Crystal data: space group P2 1/a, a = 17.803(1), b = 18.888(3), c = 12.506(3) Å, β = 107.97(2)°, Z = 2, R = 0.052, R w = 0.058. The platinum coordination is approximately square-planar, with the bond lengths Pt-Cl = 2.358(5), Pt-N = 2.15(1), Pt-P( trans to Cl) = 2.260(5), and Pt-P( trans to N) = 2.262(6) Å. All investigated compounds were cytotoxic in vitro against L1210 cells and showed no cross-resistance to cisplatin. On the other hand, no antitumor activity was observed vs L1210 leucemia in DBA 2 mice.
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