Abstract
A horse antimouse lymphocyte serum was shown to be immunosuppressive in prolonging the survival of C3H skin allografts on Balb/c mice. Despite the immunosuppressive effect of that preparation, however, mixtures of histoincompatible lymph node cells obtained from treated mice showed: (a) an increased local reactivity in the skin of the X-irradiated hamster; (b) a more rapid clearance from those intradermal injection sites; and (c) a significant, in vitro production of nonspecific lymphocytotoxic substance (s). We conclude that the liberation of cytotoxic substance (s) through mouse cell lysis is responsible, in part, for the increased local reactivity of lymph node cells obtained from immunosuppressed mice.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
