Abstract
The objective of the present study was to evaluate the in-vitro anti-cancer effects of ethanolic extract of seed of Myristica fragrans (Houtt) against seven human cancer cell lines ascribed to central nervous system, Colon cell (Colon502713,Colo205), Liver(Hep-2), Lung (A-549), Ovary OVCAR-5 and Prostrate (PC-5). The SRB assay was used to test cytotoxic activity for all the cell lines. The activity was evaluated at 100µg/ml concentration of test material. OVCAR-5 (Ovary) cell line showed highest cytotoxic activity (97%) Growth inhibition of colon 502713 and PC-5 (Prostrate) cell lines was 86%. SF-295(CNS) and Colo205 showed 73% growth inhibition, while Hep-2 (Liver) showed 72%. A-549 (Lung) showed no significant activity (50%). Our results indicate that the plant has a promising anti-cancer activity. The ethanolic extract of plant showed highest anti-cancer activity against OVCAR-5. Further investigation for active compound present in Myristica fragrans is required for cancer management and for the development of new anti- cancer drugs.
Highlights
Extract, OVCAR-5 obtained from the seeds is a popular condiment used as a spicing agent
In the present study we analyzed the cytotoxic activity of ethanolic extract of nutmeg for possible anti-cancer properties against several cells by SRB method
A perennial edible plant belonging to Annanceae family, is a berry that grows wild in the evergreen forests of West Africa and India
Summary
OVCAR-5 obtained from the seeds is a popular condiment used as a spicing agent. The seeds are embedded in a white sweet-smelling pulp and are most economically important part of the tree. They are aromatic and are used after grinding to a powder as a condiment in food providing flavor resembling that of nutmeg (Myristica fragrans). They are used as an aromatic stimulating additive to medicine and snuff. The nutmeg seed is one of four components of the fruit obtained from the nutmeg tree, Myristica frangans Houtt (Myristicaceae). In the present study we analyzed the cytotoxic activity of ethanolic extract of nutmeg for possible anti-cancer properties against several cells by SRB method
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