Cytotoxic Activity Ethanol Extract Rind of Arumanis Mango (Mangifera indica Linn.) and Ethanol Extract Rind of Kweni Mango (Mangifera odorata Griff.) by Brine Shrimp Lethality Test Method

Abstract

Mango is a plant that has many health benefits such as helping the body to ward off free radicals. Research on the cytotoxic test of the ethanol extract rind of arumanis mango (Mangifera indica Linn.) and rind of kweni mango rind (Mangifera odorata Griff.) with the brine shrimp lethality test method was to determine the cytotoxic activity of the rind. Simplicia powder of mango arumanis rind and mango kweni rind was macerated with 70% ethanol. Cytotoxic testing used various concentrations of 1000 μg/mL, 500 μg/mL, 250 μg/mL, 100 μg/mL, 50 μg/mL. From the results of phytochemical screening, the ethanol extract of the arumanis mango rind contains alkaloids, flavonoids, phenols, tannins, terpenoids, and ethanol extract of kweni mango rind (Mangifera odorata Griff.) Containing alkaloids, saponins, flavonoids, phenols, tannins, and terpenoids. The results of the cytotoxic test obtained LC50 values of 41.6869 μg/mL for arumanis mango and 29.4238 μg/mL for kweni mango with a very toxic category of <30 μg/mL and toxic of 30-1000 μg/mL. From the results of the study, it can be concluded that the ethanol extract rind of arumanis mango and the ethanol extract rind of kweni mango have cytotoxic activity.