Abstract
Cytotoxic action of maleimide derivative 1-(4-Cl-benzyl)-3-chloro-4-(CF(3)-phenylamino)-1H-pyrrole-2,5-dione toward mammalian tumor cells and its capability to interact with DNA
Highlights
Cancer is a worldwide health problem, and it is the second leading reason of human mortality after the cardiovascular diseases
It is obvious that the multifunctional anticancer agents affecting different bio-molecules and biological processes could be more efficient treatment remedies comparing to such agents with only one bio-target in the tumor cells
Human pancreatic ductal adenocarcinoma Capan-1 cells, human epidermoid cervix carcinoma KB3-1 cells and its colchicine-resistant sub-line KBC-1, that is characterized by over-expression of plasma membrane P-glycoprotein, were donated by a Collection of the Institute for Cancer Research at Vienna Medical University (Vienna, Austria)
Summary
Cancer is a worldwide health problem, and it is the second leading reason of human mortality after the cardiovascular diseases. MI-1 demonstrated anti-proliferative activity on colorectal cancer cells in vitro [6] and in vivo [7], as well as adenocarcinoma colon cells of SW620 line [8]. This compound demonstrated an anti-inflammatory activity in case of experimental chronic ulcerative colitis of rats [9] and possessed low general toxicity in laboratory animals [7, 10, 11]. It is obvious that the multifunctional anticancer agents affecting different bio-molecules and biological processes could be more efficient treatment remedies comparing to such agents with only one bio-target in the tumor cells. We addressed a potential toxic effect of MI-1 towards mammalian tumor cell lines, the drug-resistant tumor cells not studied earlier
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