Abstract
Nociceptive mediators involved in the generation of cancer pain remain poorly understood. Oral squamous cell carcinoma (SCC) produce high levels of proteases that are critical for carcinogenesis. The release of cytosol from damaged oral SCC cells, either during carcinogenesis or cancer treatment, may serve as a chemical trigger for nociception. To determine if cytosolic proteases released from cancer cells into the cancer microenvironment induce mechanical nociception, mechanically lysed cells derived from human oral SCC (HSC-3) and control human normal oral keratinocyte cultures or serum-free media (50 μl; n = 5/group) were injected into the hindpaw of female mice under light isoflurane anesthesia.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
