Cytosolic Release of Cardiac Troponin After Marathon Running

Abstract

The aims of the recent study of Mousavi et al 1 Mousavi N. Czarnecki A. Kumar K. Fallah-Rad N. Lytwyn M. Han S.-Y. Francis A. Walker J.R. Kirkpatrick I.D.C. Neilan T.G. Sharma S. Jassal D.S. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol. 2009; 103: 1467-1472 Abstract Full Text Full Text PDF PubMed Scopus (152) Google Scholar were (a) to ascertain the extent and severity of changes in cardiac function after the completion of a full marathon, using serial cardiac biomarkers, echocardiography, and cardiac magnetic resonance (CMR) imaging, and (b) to demonstrate any associations between the degree of elevation in cardiac biomarkers and the amount of delayed enhancement using CMR imaging in this patient population. The investigators found that right ventricular systolic dysfunction transiently occurred after the marathon, validated for the first time using CMR imaging. 1 Mousavi N. Czarnecki A. Kumar K. Fallah-Rad N. Lytwyn M. Han S.-Y. Francis A. Walker J.R. Kirkpatrick I.D.C. Neilan T.G. Sharma S. Jassal D.S. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol. 2009; 103: 1467-1472 Abstract Full Text Full Text PDF PubMed Scopus (152) Google Scholar No evidence of delayed enhancement of the left ventricular myocardium was found on CMR imaging. 1 Mousavi N. Czarnecki A. Kumar K. Fallah-Rad N. Lytwyn M. Han S.-Y. Francis A. Walker J.R. Kirkpatrick I.D.C. Neilan T.G. Sharma S. Jassal D.S. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol. 2009; 103: 1467-1472 Abstract Full Text Full Text PDF PubMed Scopus (152) Google Scholar The increase in cardiac troponin after the marathon was suggested to be likely due to the cytosolic release of the biomarker, not to the true breakdown of the myocytes, as confirmed by delayed-enhancement CMR imaging. 1 Mousavi N. Czarnecki A. Kumar K. Fallah-Rad N. Lytwyn M. Han S.-Y. Francis A. Walker J.R. Kirkpatrick I.D.C. Neilan T.G. Sharma S. Jassal D.S. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol. 2009; 103: 1467-1472 Abstract Full Text Full Text PDF PubMed Scopus (152) Google Scholar