Abstract
Oscillations in cytosolic free calcium concentrations ([Ca 2+] i) can be elicited in REF52 fibroblasts by three different modes of stimulation. We have previously demonstrated that [Ca 2+] i oscillations result when these cells are simultaneously depolarized and stimulated with a hormone linked to phosphoinositide breakdown. Further evidence is now presented that such oscillations are linked to fluctuations in the concentration of IP 3 and the Ca 2+ content of an IP 3-sensitive Ca 2+ store. [Ca 2+] i oscillations can also be generated in REF52 cells either by direct stimulation of G-proteins with GTPγS or AlF 4 − or by destabilizing the membrane potential and opening voltage-dependent calcium channels. This report compares the different types of oscillations and their mechanisms.
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