Abstract
All eukaryotic cells have a cytoskeleton, consisting of microtubules, intermediate filaments and microfilaments. The cytoskeletal structure of cells and cell processes in the central nervous system is diverse. The generation of animal models in which specific mutations result in underexpression of overexpression of particular intermediate filament and microtubular proteins allows assessment of the possible role of cytoskeletal abnormalities in the neurodegenerative disorders. It is suggested that overexpression of filaments is likely to be the more significant process, but that neurofibrillary change, as recognized by the neuropathologist represents the final result of failure of any of a large number of molecular processes involved in cytoskeletal protein turnover.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
