Abstract
Cytoprotective Effect of Zingiber Officinale extract on Alcohol Induced Gastric Lesion in Mice
Highlights
Spices, the predominant flavoring, coloring, and aromatic agents in food and beverages are gaining importance for their diversified uses
Cytoprotective action of ginger has been investigated using animal models of acute gastric injury induced by necrotizing agents such as ethanol
The genesis of ethanol-induced gastric lesions is multifactorial with the depletion of gastric wall mucus content as one of the involved factors
Summary
The predominant flavoring, coloring, and aromatic agents in food and beverages are gaining importance for their diversified uses. The total extract inhibited lesions by 97.5% at 1g/kg Oral administration of both aqueous and methanol ginger extract to rabbit has been reported to reduce gastric secretions (gastric juice volume, acid and pepsin output). The plant contains active materials which for some of them ulcer protective properties have been identified 6- ginger sulfonic acid and three monoacyldigalactosyl glycerols including ginger glycolipid A,B,C have been isolated from dried rhizome of Zingiber Officinale which are potent anti-ulcer components Yoshikawa et al [10]. B) Results of one study fore effects of three herbal medicine including Zingiber Officinale on gastric ulceration and secretion in rats indicated significant protection against stress, aspirin and pylorus ligation. The results of this study demonstrated that the extract in the dose 500mg/kg orally exerted highly significant cryoprotection and prevented occurrence of gastric ulcers induced by non- steroidal antiinflammatory drugs
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