Abstract
We aimed to investigate whether oocyte morphologic abnormalities affected cycle outcome in poor responder infertile women who fulfilled the Bologna criteria. Data were obtained from infertile couples who underwent ICSI and embryo transfer at the Zeynep Kamil Maternity and Children’s Health Training and Research Hospital Assisted Reproduction Unit in İstanbul, Turkey. They were allocated to two groups: Group A, poor responders, and Group B, normal responders. All morphological abnormalities of oocytes retrieved were reviewed and grouped as cytoplasmic abnormalities or extracytoplasmic abnormalities. All morphological features were compared between the poor and normal responder groups. ICSI cycle outcomes were described as biochemical pregnancy, fertilization rate, number of top-quality zygotes, top-quality zygote rate, number of embryos transferred, and number of top-quality embryos transferred. The relation between each morphological feature and ICSI outcomes was investigated in each group. The results showed no difference between the groups in terms of morphological features of oocytes. The relation between ICSI cycle outcomes and each oocyte morphological feature was compared in the poor and normal responder groups. Presence of cytoplasmic morphological abnormality was found to significantly correlate with the fertilization rate (P = 0.019) in poor responders. Our data show that oocyte cytoplasmic abnormalities significantly reduce fertilization achievement in poor responders.
Highlights
Delay in childbearing causes a rise in the demand for assisted reproductive technologies (ARTs)
Our data show that oocyte cytoplasmic abnormalities significantly reduce fertilization achievement in poor responders
Etiological factors associated with a poor response to controlled ovarian hyperstimulation (COH) are advanced age, iatrogenic or accidental ovarian damage, previous ovarian surgery, serious endometriosis, and numerical and/or structural chromosomal aberrations [3,4,5]
Summary
Delay in childbearing causes a rise in the demand for assisted reproductive technologies (ARTs). Infertility clinics increasingly encounter women with low ovarian reserve and poor ovarian response (POR) to conventional ovarian stimulation [1]. In 2011, the first systematic definition of poor responder women was developed by the European Society of Human Reproduction and Embryology and published as the Bologna criteria [2]. Obtaining enough oocytes in the ART cycles. Oocyte quality in poor responder women and its consequence in ICSI cycles was the main concern in this. We aimed to investigate whether there is a difference between normal and poor responder women in terms of morphologic abnormities of oocytes and whether these abnormalities have any effect on clinical and laboratory outcomes in poor responder women who fulfill the Bologna criteria
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