Abstract
Adriamycin and daunomycin are structurally related antibiotics used in the clinical management of neoplastic diseases. However, adriamycin has exhibited a higher therapeutic index against a wide variety of tumors and thus is currently of greater clinical interest. Like daunomycin, adriamycin produces a delayed, irreversible, lethal cardiac toxicity. The present study was initiated to compare the cytopathology of cardiac tissue from adriamycin-treated mice with previous ultrastructural observations of myocardium from daunomycin-treated rodents.Four to eight days after drug administration, myocardium from the ventricles of 8 moribund BDF1 male mice which received a single intraperitoneal dose of adriamycin (20 mg/kg), and from controls dosed with physiologic saline, was fixed in glutaraldehyde or Karnovsky's glutaraldehyde-paraformaldehyde and prepared for electron microscopy.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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