Abstract
BackgroundCytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.ResultsCMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).ConclusionsIn the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.
Highlights
Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes
The aim of the present study was to explore the association between CMV seropositivity, CMV IgG antibody level, and indicators of glucose regulation assessed by means of the frequency of diagnosis of type 2 diabetes, level of glycated haemoglobin (HbA1c) and level of nonfasting glucose in a cohort of the oldest old in the general population
In the present study, CMV seropositivity was associated with indicators of glucose regulation in terms of more frequent diagnoses of type 2 diabetes, elevated levels of HbA1c and non-fasting glucose in very elderly people infected with this virus
Summary
Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. While only one third of individuals with insulin resistance will develop type 2 diabetes, many others do not because their β-cells are able to respond adequately to the increased demand for insulin [1,2]. The reason for this heterogeneity is not. CMV seropositivity was clustered as one parameter of the “Immune Risk Profile”
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