Cytomegalovirus infection in patients with lung tuberculosis

Abstract

Introduction: Wide spread of cytomegalovirus infections (CMVI) among immunosuppressive patients is actual problem at present because of high mortality in this group. Aim of the Study: Frequency estimation and influence on disease progression of CMVI in patients with lung tuberculosis with or without HIV-infection. Methods: 233 patients with progressive lung tuberculosis were examined, 144 (61,8%) — with HIV-infection (death rate 27,8%), 89 (38,2%) — without HIV-infection (death rate 12,4%). Diagnosis of tuberculosis was made on the results of clinical and X-ray examination. All patients with HIV-infection had clinical category C1-C3. Samples of blood were tested with immunoferment analysis to detect the antigens and quantitative rate of antibodies IgM and IgG in serum for cytomegalovirus (CMV). Algorithm was developed to estimate the activity of CMVI depending on laboratory data. The main indicator of activity was simultaneously increased levels of antibodies IgM and IgG in samples of blood serum. Results: Analysis of frequency rates of CMVI in patients with lung tuberculosis without HIV-infection showed that acute phase of CMV was tested in 19% and latency – in 94%, whereas in HIV/TB patients this was respectively 27% and 85%. At once among dead this was respectively 27,2% and 100% versus 25% and 62,5% in HIV/TB. Conclusions: Frequency of CMVI in patients with lung tuberculosis is rather high and doesn9t correlate with HIV-infection presence. High levels of markers of CMVI may be considered as death predictors, especially in HIV-negative TB patients.