Abstract
CYTOMEGALOVIRUS (CMV), one of the human herpes group viruses, is the most important microbial pathogen affecting organ transplant recipients, contributing directly and indirectly to both morbidity and mortality in these patients. Three main patterns of CMV infection have been described: primary CMV infection, reactivation of CMV infection, and superinfection with a new strain of CMV virus. The clinical effects of CMV in transplant recipients can be grouped into four categories: (1) clinical infectious disease syndromes by the virus itself; (2) the production of an immunosuppressed state, which exceeds that caused by the immunosuppressive drugs being administered; (3) production of acute and chronic allograft injury, which is different from classic allograft rejection; and (4) a possible role in the development of malignancies. In this study we evaluated the incidence of CMV seropositivity and infection in our renal allograft recipients retrospectively. We also assessed whether steroid pulse treatment was a predisposing factor for CMV seroconversion or reactivation, and evaluated the effect of CMV infection on allograft function.
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