Abstract
Problem statement: Fetal loss and abortion are responsible for significant emotional distress for couples desiring children. There are many documents which support the role of some certain asymptomatic infections such as Cytomegalovirus (CMV) in spontaneous abortion. This study was aimed to evaluate the prevalence of seropositivity for CMV IgG and IgM in women with abortion and compare it with normal women with no previous history of abortion. Approach: This case-control study was carried out in Shariatee hospital of Hormozgan University of medical sciences, during 2003-2004. A number of 250 women with definite diagnosis of previous abortion and 200 matched women with normal full term delivery and negative history of miscarriage as controls were studied as case and control groups. Serum samples were obtained from participants and a demographic questionnaire was also filled for each of them. All serum samples were then tested using ELISA method for detection of anti-CMV IgM and IgG Antibodies. Data was analyzed, using SPSS software (chi square and t-test). Results: The average age was 25.6±7.6 years in case group and 25.3±6.5 years in control group. The number and percentage for CMV-IgG was 235(94%) and 150(75%) in case and control groups, respectively (p-value = 0.0001). In case group 13(5.2%) women were positive for CMV-IgM, while no positive sample was detected in control group (p-value = 0.0001). Conclusion: This study showed higher prevalence of seropositivity for CMV in women with spontaneous abortion comparing to women with normal full term delivery and suggest that cytomegalovirus plays a significant role in abortion.
Highlights
Up to 15% of intrauterine CMV infections result in symptomatic congenital disease at birth and 10 to 15% of those born with asymptomatic congenital CMV will develop significant clinical sequelae in infancy (Boppana et al, 1992; Dahle et al, 2000; Fowler and Boppana, 2006)
The presence of CMV-specific Immunoglobulin M (IgM) may not be indicative of primary infection, since it is produced during reactivation and re infection (Nielsen et al, 1988)
We conducted a case-control study in the delivery population of University Hospital (Hormozgan province, Iran) between Feb. 2003-Jun. 2004, to investigate whether prevalence of AntiCytomegalovirus antibodies (IgM and IgG) in two groups of women with spontaneous abortion and without history of abortion to determine a relation between the role of seropositivity for this virus and abortion as well as factors which might have an influence in the pathogenesis of these infections
Summary
Human Cytomegalovirus (CMV) is the most common cause of congenital malformation resulting from viral intrauterine infection in developed countries (Demmler, 1991; Gaytant et al, 2002; Stagno et al, 1986). Some researches have conducted to determine the role of (CMV) infection in pregnancy and some of them showed significant relation between this infection and spontaneous abortion (Enders et al, 2001; Cook et al, 1993; Luerti et al, 1983). The presence of CMV-specific Immunoglobulin M (IgM) may not be indicative of primary infection, since it is produced during reactivation and re infection (Nielsen et al, 1988). IgG of low avidity are produced at the onset of infections and subsequent maturation of the antibody increases its avidity over time.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
