Cytomegalovirus Genotypes gB1 and gH1 Are the Most Predominant Genotypes among Renal Transplant Recipients in Kuwait

Abstract

Background The human cytomegalovirus (HCMV) is a common pathogen responsible for asymptomatic and persistent infections in healthy individuals. However, cytomegalovirus infections are a major cause of morbidity and mortality in immunocompromised patients, especially in recipients of solid-organ transplants and AIDS patients. Methods HCMV DNA from 42 patients who received kidney transplants between 2004 and 2008 were subjected to polymerase chain reaction and restriction fragment length polymorphism to identify HCMV gB and gH genotypes. Results HCMV gB1 and gH1 genotypes were the most the predominant HCMV genotypes ( P < .05, P < .05, respectively). In addition, both HCMV gB1 and gH1 genotype were significantly more often associated with the development of fever with leukopenia and severe HCMV disease than other gB or gH2 genotypes. No significant differences were observed among viral loads between the HCMV genotypes among infected individuals. Conclusion This study demonstrated the prevalence and role of HCMV genotypes in infection and disease in renal transplant patients in Kuwait.