Abstract
The review article considers modern data of genetic variety cytomegalovirus , circulating in the world, various approaches to genotyping of cytomegalovirus clinical isolates are represented, the characteristic of basic polymorphic genes, used for strains differentiation is given, the linkage between the strain specific genotypes and the clinical manifestations of cytomegalovirus infection in patients of highrisk groups is described. The information of cytomegalovirus genotypes is necessary for realization cytomegalovirus infection-epidemiological surveillance and development of effective vaccine.
Highlights
The review article considers modern data of genetic variety cytomegalovirus, circulating in the world, various approaches to genotyping of cytomegalovirus clinical isolates are represented, the characteristic of basic polymorphic genes, used for strains differentiation is given, the linkage between the strain specific genotypes and the clinical manifestations of cytomegalovirus infection in patients of highrisk groups is described
The information of cytomegalovirus genotypes is necessary for realization cytomegalovirus infection-epidemiological surveillance and development of effective vaccine
Genetic linkage among human cytomegalovirus glycoprotein N (gN) and gO genes, with evidence for recombination from congenitally and post-natally infected Japanese infants/ H
Summary
The review article considers modern data of genetic variety cytomegalovirus , circulating in the world, various approaches to genotyping of cytomegalovirus clinical isolates are represented, the characteristic of basic polymorphic genes, used for strains differentiation is given, the linkage between the strain specific genotypes and the clinical manifestations of cytomegalovirus infection in patients of highrisk groups is described. Общий процент вариабельности гена UL144 у ЦМВ-изолятов составляет 33% [3]. При исследовании клинических изолятов для UL139 было выделено три основных группы G1, G2 и G3, две из которых были разделены на подгруппы: G1a, G1b, G1c, G2a и G2b [16]. Частота встречаемости gB-генотипов у пациентов, перенесших пересадку органов, по данным разных исследователей, варьирует, но чаще всего в этой группе пациентов выявляются генотипы gB3, gB1 и gB2.
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