Abstract
The risk of progressing from Mycobacterium tuberculosis infection to tuberculosis disease depends on the age at the time since infection. There is a complex relationship between tuberculosis and other infectious diseases; infections potentially alter the balance between immune responses that contain tuberculosis and those that allow disease progression. Understanding these associations provides potential insights into tuberculosis pathogenesis, can be used to assess progression risk in people with tuberculosis infection, and provides opportunities to prevent tuberculosis disease.
Highlights
The risk of progressing from Mycobacterium tuberculosis infection to tuberculosis disease depends on the age at the time since infection
Infants who had acquired a cytomegalovirus infection before age 24 months had an increased risk of tuberculosis disease between ages 1 and 9 years and those with a high cytomegalovirus viral load seem to be at highest risk
Cytomegalovirus infection was not associated with tuberculin skin test conversion, suggesting that it did not increase the risk of tuberculosis infection but affected progression to tuberculosis disease.[4]
Summary
The risk of progressing from Mycobacterium tuberculosis infection to tuberculosis disease depends on the age at the time since infection. Understanding these associations provides potential insights into tuberculosis pathogenesis, can be used to assess progression risk in people with tuberculosis infection, and provides opportunities to prevent tuberculosis disease.[1]
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