Abstract
Specific antigen recognition is required to stimulate generation of a cytolytic T lymphocyte (CTL1) response and to allow the resulting effector CTLs to bind and lyse the target cells. Reliable assays allow in vitro assessment of stimulation of a primary and secondary response and of the effector-target interaction. The antigens required to trigger generation of a response are the same as those required to allow binding and lysis by the effector CTL.
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