Abstract
Micropapillary carcinoma (MPC) is a rare aggressive tumor, which generally accompanies the primary carcinoma of the organ of its origin, while the pure form is extremely uncommon. Angiolymphatic involvement is widespread and a considerable proportion of the cases present with metastases. The current study presents eight pure MPC cases arising from the breast (n=3), urinary bladder (n=3), parotid gland (n=1) and lung (n=1, presenting with pericardial effusion), with the cytological findings. The eight patients included three female and five male cases aged between 48 and 74 years. The most common cytological findings were three-dimensional aggregates, cell clusters with angulated or scalloped borders, single cells with a columnar configuration and eccentric nuclei, and high-grade nuclear features. Histopathological sections showed accompanying in situ ductal carcinoma in the cases of MPC arising in the parotid gland and breast (n=3), and one case in the bladder exhibited only in situ MPC. The average follow-up period was 20 months (range, 6–54 months) and, during this period, three patients succumbed to the disease. At present, four patients are alive with disease and one patient is alive and disease-free. In conclusion, cytology is an important tool for the diagnosis and management of MPC.
Highlights
Micropapillary carcinoma (MPC) is an uncommon morphology typically observed within the context of the borderline serous carcinoma of the ovary [1]
The appearance is reminiscent of enlarged angiolymphatic vessels and is associated with a more aggressive clinical course and a higher rate of lymph node metastasis compared with the typical carcinomas of the organ of origin
In addition to borderline serous carcinoma of the ovary, MPC has been identified in other sites, such as the stomach, colon and parotid gland, over the last two decades [2,3,4,5,6,7,8,9,10]
Summary
The diagnosis of pure MPC was determined and showed widespread intralymphatic tumor thrombi. MPC metastasis was present in six axillary lymph nodes and the pathological stage was pT3A. FNA with ultrasonography was performed and the diagnosis of malignant cytology, MPC was determined. The diagnosis of pure MPC was determined and widespread intralymphatic tumor thrombi were observed. MPC metastasis was present in seven axillary lymph nodes together with tumor invasion of the chest wall. Micropapilloma carcinoma metastasis was present in eight axillary lymph nodes and the pathological stage was pT3B. Cystoscopy revealed a solid ulcerated mass of 1 cm in diameter on the right lateral wall and a washout cytology sample was obtained. Histological evaluation revealed a pure MPC with widespread lymphatic invasion, with a pathological stage of pT2.
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