Cytological Diagnosis of Caltilagious Tumors

Abstract

14 cases of clatilagious bone tumor (5 enchondroma, a benign chondroblastoma, 3 chondromyxoid fibroma and 5 chondrosarcoma) were tried to differentiate by the cytological diagnostic procedure.More than 15 smears per one cases were prepared, and at least 5 were stained by May-Grünwald and Giemsa's method which gave us the most reliable morphological picture. The residual smears were reserved for additional special stains, such as PAS, sudan III, alkaline phosphatase and acid phosphatase.Besides morphological details, appreciatable items for the differential diagnosis among each tumors were 1) difference in staining intensity of materials, 2) grade of exfoliation of tumor cells, 3) extracellular substance, 4) cytoplasmic component, and 5) characteristic grouping of tumor cells.Generally, non-epithelial tumor cell show variegated forms and some benign, caltilagious tumors such as chondromyxoid fibroma and benign chondroblastoma have mimic signs to cancer cells, but such tumors are rather easily distinguished from their own characteristic cytologic pictures.