Cytological characteristics of the Regenerative Epithelium and the Atypical Epithelium of the Stomach

Abstract

Regeneration is the common plenomenon for restoring of ulcer and erosion on the superficial layer of the polyp or the chronic gastritis.These cells on the regeneration epithelium showsometimes very active figurs which are sometimesdifficult of differentiate from cancer cells.During last 4 years, cytological false positive caseswere 12 among 569 of gastric ulcer and 3 out of 60 in cases of gasting benign polyp.They comprised of 2.1% in gastric ulcer casesand 5% in gastric benign polyp.I compared these cells of fals epositive cases withearly gastric cytologically.In conclusioin, incidence of abnormal shape ofnucleus like as identations etc. under 15μ, a in diameter is higher in cancer cellsthan that of regenrative epithelial cells, and cells with many round or ovaln uclei without so remarkable abnormality of shape are seen rather in benign cases.Cells with increased nuclear-cytoplasmic ratio, hyperchromasia of nucleus with fine granular chromatin over 15μ in diameter is seen in rather malignant cases. And also remarkable abnormality ofnucleus with granularly dotted chromatin is malignant.These findings are different with Papanicolaou and May-Grünwald-Giemsa staining in details, so carefulobservation based on characteristics of these staining is necessary.On the other hand, cells exfoliated from atypicalepithelium of the stomach called as border line lesion show slender cytoplasm with slender nucleus, slightly increased nuclear-cytoplasmic ratio, and slight atypism of nucleus with close superimposition.But some cases in this group show cytologicalpositive result. Among them, small early gastriccancer is seen in some cases.So the cytological examinaton is important forthe clinical analysis of atypical epithelium of thestomach.