Abstract
Oropharyngeal tumor is the eight most common cause of cancer death worldwide. Among the causes of oropharyngeal carcinoma significant are cigarette smoking, abuse of alcohol, multi-partners, high risk HPV (Human Papillomavirus) and etc. Cytological material (oral Pap smear) was taken from oral fundus and cheek mucous by the cytobrush. 47 participants with cervix pathology and 42 participants of the control group were investigated. Oral smears were stained by the Papanicolaou method and were diagnosed by a double blind method. After the cytological examination, we carried out detecting low and high risk HPV by chromogenic in-situ hy-bridization (CISH method) to use a positive and negative control. The quantitative statistical analysis was performed by SPSS V.19.0. Numeral data were processed using Pearson correlation and X2 tests. Confidence interval of 95% was regarded statistically significant. Study group’s oral pap smear with atypical cytology was detected in 61.7%. Atypical cytological changes in the control group were confirmed in 38.0%. High risk HPV detection by the CISH, in study group, showed positivity in 46.8% and in the control group—in 4.8%. Participants with cervix pathology will be considered as a risk-group to develop oropharyngeal tumor. Screening program for oropharyngeal cancer combines Pap smear and high risk HPV test together. For the control group, it is recommended to use oral pap smear and in the case of atypical changes using high risk HPV test too.
Highlights
Oropharyngeal tumor is the eight most common cause of cancer death worldwide
We aimed to investigate oral cavity smear, cytologically, in women with dysplastic changes of cervix, with subsequent HPV testing
We investigated 53 participants with cervix pathology and 46 participants of the control group
Summary
Oropharyngeal tumor is the eight most common cause of cancer death worldwide. This year 45,780 cases of oropharyngeal cancer have been diagnosed in the United States. This cancer is probably increasing because of infection with HPV. If the cancer is diagnosed at an early stage, the 5-year survival rate is 83%. In case of distant metastases in the body this number is 37% [1]-[3]. This incidence varies widely among different regions. Advance is that oropharyngeal tumors develop from the pre-malignant condition’s further progression and we are eligible to detect the disease earlier and prevent further complications using cytological investigation and HPV test [7]-[9]
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