Abstract
The cytological effects have been studied of methotrexate administered in single doses on a hypertriploid ascites tumour in the mouse, which seems to be sensitive to this drug. The drug produced almost total stoppage of the mitotic index, which was maintained for 50 h after administration. The occurrence of fractures in both chromosomes and chromatids in metaphase was the most frequently observed anomaly, sometimes reaching an incidence of 100%. Chromosomal bridges were found in the anaphase in up to 60% of the cells.
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