Abstract
An attempt was made to elucidate the cytological characteristics of chondrogenic tumors of bone for the purpose of differential diagnosis. Materials were obtained by needle biopsy aspiration, curettage, resected specimens or pleural effusion of enchondroma (four cases), osteochondroma, chondroblastoma, conventional chondrosarcoma, chondroblastic osteosarcoma (three respectively) and one dedifferentiated chondrosarcoma. Cartilage matrix closely associated with tumor cells wase recognized to varying degrees in all cases. Nuclear features such as enlarged nuclei, double or multiple nuclei, bizarre nuclei and high N/C ratio, in addition to the abundance of cells obtained appeared useful for the cytologic interpretation of chondrosarcoma. Chondroblastomas revealed characteristic cytology features different from those of giant cell tumor and the immunohistochemical demonstration of S-100 protein, which is not seen in the latter was especially useful. Measurement of average cell and nuclear diameters exhibited different characteristic histograms between benign and malignant chondrogenic tumors.
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