Abstract
We studied the time course of depopulation and repopulation of epidermal cells in guinea-pig skin after β irradiation from a ${}^{90}{\rm Sr}-{}^{90}{\rm Y}$ sealed source. Immediately after clipping, one site on each flank was locally irradiated with 1000, 2200, 3000, or 5000 rad (six sites per animal). The changes in number of basal cells, labeling index (LI), and the appearance of clusters of ${}^{3}{\rm H}\text{-thymidine-labeled}$ basal cells (two or more pulse-labeled cells in direct contact) were observed. Maximum cell loss of recognizable basal cells of 20% on Day 8, 60% on Day 12, and 75% on Day 15 occurred after irradiation with 1000, 2200, and 3000 rad, respectively. The data for 5000 rad was similar to that in 3000-rad-irradiated epidermis. Repopulation (as evidenced by increase in LI and clusters of labeled cells) at all doses began on about the day of maximal cell loss. Regeneration occurred from survivors within the irradiated area after 1000 and 2200 rad, and was completed in 5 days (i.e.,...
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