Abstract
Toxoplasmosis is one of the most important zoonotic diseases worldwide caused by Toxoplasma gondii that leads to abortion or hydrocephalus during pregnancy. It’s a comparative cross-sectional one designed to assess immunoglobulins and cytokines in pregnant women. A total of 300 venous blood samples were collected from each pregnant woman and centrifuged to obtain serum. Patient’s information was recorded in a questionnaire previously designed for the purpose of analysis. In addition, 40 uninfected women were enrolled in the study as control group to assess the level of IL8 and IL17 cytokines. The overall seropositive rate of Toxoplasma gondii infection was 22.6%. Within the positive cases of study population, only 16 and 13 showed positive results of IL8, IL17 respectively. The results showed highly significant increase in the mean serum level of IL8 (210.25pg/ml) and IL17 (203.15 pg/ml) when compared to the control group who showed 68.9 pg/ml and 54.8 pg/ml respectively. The serum level of proinflammatory cytokines investigated in this study seems to be increased in patients with serological evidence of Toxoplasma gondii infection. Our study concludes that IL-17 and IL-8 involved in the induction of inflammation and toxoplasmosis disease.
Highlights
Toxoplasmosis is a widespread parasitic zoonosis that caused by Toxoplasma gondii and occurs throughout the world
The aims of this study were: 1-to assess seroprevalences (IgG and IgM) of T. gondii in women repeated spontaneous abortion and to find out if there is any significant relationship between this infection and repeated spontaneous abortion. 2-To determine the role of IL-8 and IL-17 in the immuno-regulatory pathways involved in repeated spontaneous abortion in women with or without toxoplasmosis
A total of 300 pregnant women were enrolled in this study with mean (SD) age of 30.28(6.4) years and 40 non infected pregnant women were enrolled as control group
Summary
Toxoplasmosis is a widespread parasitic zoonosis that caused by Toxoplasma gondii and occurs throughout the world. It can infect almost all the warm blooded animals, including human beings[1]. Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect an extremely wide host range, from birds to mammals, including humans. The definitive host for T. gondii is cat and the intermediate hosts are mammals and birds. The infection is acquired mainly by eating food or drinking water contaminated with oocysts or tissue cysts of T. gondii[2]. Toxoplasmosis is the most common infections associated with unfavorable outcome of pregnancy[3]
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