Abstract
Publisher Summary This chapter focuses on the role of cytokines in experimental pulmonary fibrosis induced in mice by bleomycin or dust particles and various other types of pulmonary fibrosis such as idiopathic pulmonary fibrosis and sarcoidosis. The role of cytokines can be explored using different methods: (l) tissue extraction is obviously the most direct approach and has been performed successfully for transforming growth factor (TGF)- β during bleomycin-induced pulmonary fibrosis, (2) RNA extraction and evaluation of the mRNA content by Northern blotting have been performed for several cytokines, including interleukin-1, tumor necrosis factor, TGF, and platelet-derived growth factor, and (3) another approach is isolation and exploration of cellular components; alveolar leukocytes and macrophages, freshly prepared or after culture, have been extensively explored in the context of pulmonary fibrosis.
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