Abstract
Cytokines in Systemic Lupus Erythematosus
Highlights
Cytokine dysregulation is likely to play a role in the loss of immune tolerance that leads to lupus and in the damage resulting from the disease
IL-17, is dysregulated in lupus enhancing the pathogenesis of the disease
Many of the genes that are associated with risk for lupus are cytokines, regulators of cytokines, or downstream members of cytokine pathways. Examples of these factors that are associated with risk for lupus and are examined in this special issue include Interferon Alpha, Interferon Kappa, Monocyte Chemoattractant Protein, Adiponectin, IL-10, IL-21, and Phosphoinositide Kinase
Summary
Cytokine dysregulation is likely to play a role in the loss of immune tolerance that leads to lupus and in the damage resulting from the disease. Recent research, including genome-wide genetic and transcriptional analysis has revealed potential roles for many different factors. A discussion of therapeutic cytokine inhibition, especially targeting of interferon alpha, is included in this issue. Included is an analysis of unintended consequences of such treatments, where targeting of a cytokine (TNF-alpha) to treat rheumatoid arthritis can accelerate loss of tolerance and lupus-like autoimmunity.
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