Abstract
Cytokines are produced by almost any cell and function as important mediators of cell activation, differentiation and proliferation. As more cytokines become available several clinical trials have been performed using cytokines to treat skin diseases. The broadest clinical experience exists with the use of interferons (IFN). Treatment of condylomata acuminata with IFN as an adjuvant therapy appears to be promising. Cutaneous T-cell lymphoma may be treated successfully with IFNα in combination with retinoids and PUVA, respectively. Treatment of malignant melanoma with systemic IFN alone turned out not to be superior to other therapies. Administration of IFNα in AIDS-assoc-iated Kaposi's sarcoma resulted in regression rates of between 20% and 50%. IFNα applied intralesionally was successful in actinic keratosis, basal and squamous cell carcinomas. Other dermatoses treated with some success with IFN include atopic dermatitis, systemic mastocytosis, lupus erythematosus, Behset's disease, keloids, granulo-mato...
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