Abstract
Multiple myeloma develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. MM cells produce a variety of cytokines to stimulate bone resorption by enhancing osteoclast formation and suppress bone formation by inhibiting osteoblast differentiation, leading to bone destruction and rapid loss of bone. In these lesions, osteoclasts and bone marrow stromal cells/immature osteoblasts create a microenvironment suitable for myeloma cell growth and survival, thereby forming a vicious cycle between bone destruction and myeloma expansion.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
