Abstract
Association studies of proinflammatory and anti-inflammatory cytokines single nucleotide polymorphisms with multiple sclerosis (MS) in population with different ethnic background have shown inconsistent results. To study the possible role of tumor necrosis factor-α G-308A, interleukin-6G-174C, interleukin-10 C-592A, C-819T, G-1082A, transforming growth factor (TGF)-β (codons 10 and 25), and interferon-γ T+874A polymorphisms in susceptibility to MS in Iranian population, DNA samples from 98 patients and 97 healthy controls were genotyped using polymerase chain reaction- sequence-specific primers. Analysis of the genotypes revealed a significant lower frequencies of tumor necrosis factor-a GA and TGF β C/C G/G genotypes and higher frequency of TGF β T/C G/C genotype in patients (P<0.05). Our data suggest that these polymorphisms play a role in susceptibility to MS, which is possibly mediated by dysregulated production of these cytokines.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
