Abstract
T Cells The pathogenic role of the T helper 17 (TH17) subset of CD4+ T cells in multiple immune-mediated diseases has prompted close scrutiny of the cytokine signals that promote differentiation and maintenance of these cells. Interleukin-6 (IL-6) and transforming growth factor–β are key cytokines for TH17 commitment by naive T cells, whereas IL-23 supports maintenance of a TH17 identity. Harbour et al. investigated whether persistent IL-6 signaling is also needed to sustain TH17 cell functions. Mouse T cells deficient in an IL-6 receptor component could not maintain a TH17 phenotype and were attenuated in their ability to elicit colitis in an in vivo cell transfer model. These studies suggest that there are additional molecular targets for pharmacological interventions aimed at antagonizing pathogenic TH17 immunity. Sci. Immunol. 5 , eaaw2262 (2020).
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