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Abstract
Cytokine therapy for proteoglycan-induced arthritis
Highlights
The destructive inflammation in the rheumatoid synovium is associated with a dominant Th1-type immune response
A PG-specific cytokine response was evident in splenocytes after the third injection (28 days) and the ratio of increase of IFN-? production was much higher than for either IL-4 or IL-10
Treatment with IL-4 starting in the pre-arthritic period prevented any of the histological changes in the joints that were evident in the phosphate buffered saline (PBS)-treated, PG-immunised group
Summary
The destructive inflammation in the rheumatoid synovium is associated with a dominant Th1-type immune response. A propensity to develop a vigorous Th1-type response may predispose an individual to severe rheumatoid arthritis. BALB/c mice are an inbred strain which display a propensity for dominant Th2 responses. These mice develop only mild arthritis following challenge with Borrelia burgdorferi. Immunisation of BALB/c mice with human cartilage proteoglycan (PG) is known to induce a CD4+ T cell mediated progressive polyarthritis and spondylitis. To examine the cytokine profile of PG-specific T cells in BALB/c mice with PG-induced arthritis and to investigate the effect of systemic Th2 cytokine administration prior to disease development and during acute arthritis
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