Cytokine tatus in patients with recurrent herpes infection

A S Akmeeva,A E Elkham,R B Zhamborova,A Ya Aloeva,T Sh Tagirova,A M Kakhidov,D M Altamirova,Z A Kambachokova,I D Abdulkadyrova

doi:10.37489/0235-2990-2021-66-5-6-35-39

Abstract

The study of the concentration of the main pro-inﬂammatory cytokines (IL-1β, IL-6 and TNF) in the blood serum of 48 patients with recurrent chronic herpesvirus infection was carried out. A signiﬁcant increase of cytokine levels with the maximum values during the height of the disease was established. During the period of clinical symptoms’ subsidence, a decrease in their concentration with incomplete normalization is observed during the period of convalescence. Changes in the level of IL-1β, IL-6 and TNF in the blood serum of patients with recurrent herpesvirus infection depended on the period of the disease and the severity of the pathological process.

Highlights

Герпесвирусы широко распространены в человеческой популяции и обладают большим разнообразием клинических проявлений, поражая различные органы и ткани
Changes in the level of IL-1β, IL-6 and TNF in the blood serum of patients with recurrent herpesvirus infection depended on the period of the disease and the severity of the pathological process
Как и при других хронических заболеваниях с персистенцией вируса, развиваются иммунодефицитные состояния, обусловленные недостаточностью клеточных и гуморальных механизмов иммунологической резистентности, в частности с дефектами цитокиновой системы [8]