CYTOKINE STORM 15 DAYS AFTER VIRAL-INDUCED VACCINE, MACROPHAGIC ACTIVATION SYNDROME OR VACCINE-INDUCED IMMUNE THROMBOCYTOPENIA (VITT) SYNDROME?

Abstract

Vaccination is considered the most promising approach to ending or containing the 2019 coronavirus (COVID-19) pandemic. Available vaccines have proven to be very safe and effective. Nevertheless, post vaccination complications have been described. We report the case of a 26-year-old female patient admitted for management of severe viral pneumonitis due to SARS COV2, 15 days after the 1st dose of the vaccine, whose investigations suggest a macrophagic activation syndrome or vaccine-induced immune thrombocytopenia syndrome (VITT) Macrophagic activation syndrome (MAS) is observed in a multitude of clinical situations encountered in adults. It is characterized by a series of non-specific clinical and biological signs, the combination of which should raise the suspicion of the diagnosis and lead to a cytological or histological examination to confirm it. Its occurrence requires a fairly exhaustive etiological work-up. It is a serious pathology, with a severe prognosis and a poorly codified treatment [1, 2].The objective of our work is to report a case of MAS strongly suspected following an infection due to COVID in a young 26 year old patient, 15 days after the 1st dose of the vaccine, a Vaccine-induced Thrombotic Thrombocytopenia (VITT) not to be eliminated either.