CYTOKINE PROFILE, EEG AND CLINICAL PARAMETERS IN AUTISM SPECTRUM DISORDERS

Abstract

Event Abstract Back to Event CYTOKINE PROFILE, EEG AND CLINICAL PARAMETERS IN AUTISM SPECTRUM DISORDERS Martha C. Inga Jácome1* 1 Medical Doctor, Inmunology, Ecuador MD.Inga-Jácome Martha Cecilia, Medical SchoolHavana University Immunology Dept.,131 /145 Cubanacan Playa Havana-Cuba, e-mail: dra.marthai@nauta.cu, marthytuamiga@yahoo.com, martha@cngen.sld.cu. MD. PhD. Morales Chacòn Lilia Maria1 International Center for Neurological Restoration, Neurophysiology Dept. Av. 25 # 15805/ 158 and 160 Playa Havana-Cuba e-mail: lily@neuro.ciren.cu. MD.BelaoniaHuamanCamilaGregoria, Medical SchoolHavana University Immunology Dept.,131 esq 145 Cubanacan Playa Havana, Cuba, e-mail:cagbh@nauta.cu. MD.García Sanchez Manuel Benjamin, Medical SchoolHavana University, Neurophysiology Dept. 131 esq 145 Cubanacan Playa Havana, Cuba, e-mail:benjamingarcia@nauta.cu MD. PhD Vera Cuesta Hector, International Center for Neurological Restoration, Neurology Dept. Av. 25 # 15805/ 158 and 160 Playa Havana-Cuba e-mail: verac@neuro.ciren.cu MD.Maragoto Carlos, International Center for Neurological Restoration. Neurology Dept. Av. 25 # 15805/ 158 and 160 Playa Havana-Cuba e-mail: maragoto@neuro.ciren.cu MD. PhDGonçalves Carlos Alberto,BiochemistryDepartment of Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Rio Grande Del Sur Brazile-mail:casg@ufrgs.br MD. PhD Robinson-AgramonteMaria de los Angeles1 International CenterforNeurologicalRestoration. Dept. Av. 25 # 15805/ 158 and 160 Playa Havana-Cubae-mail:maria.robinson@infomed.sld.cu Studies have demonstrated that neuroinflammation underlies the autism development, but it not always evidences point towards how this aberrant immune function affects an abnormal neural development and the impaired behavioral outcome in (Autistic Spectrum Disorder) ASD. The objective of this study shows the probable contribution of immune changes to neurobiological events in autism. The participants were 17 children, between 3 to 9 years old, classified as ASD according to Diagnostic and Statistical Manual of Mental Disorders 4th Edition, (DMS-IV). The severity of the disease was measured by the Childhood Autism Rating Scale (CARS) and the heterogeneity of functioning of ASD children was also considered. Each observation was analyzed between the ASD (groups- subgroups) and controls. Cytokine profile was assessed in plasma samples of ASD patients and age-matched typically developing (AMTD). Plasma cytokine detection was carried out using a sandwich ELISA kit following the manufacturer´s instruction (Quantikine ELISA). Statistical analysis reaches significant increases in plasma levels of IL-1β, IL-6, IL-17, IL-12p40 and IL-12p70 cytokines in autistic group compared with AMTD (p<0.05). Significant differences between clinical variables and cytokines were also observed in ASD clinical subgroups. Increased IL-4 cytokine level was associated with paroxistic activity in the EEG, focused to a particular brain region, as well as some changes in cytokines levels were observed regarding the EEG changes. The present result drives novel association between clinical and neurobiological markers in ASD and confirms the hypothesis on relevant contact points between clinical and neuroinflammatory events in autism. Keywords: Neuroinflammation; Cytokines, autistic spectrum disorder (ASD), neuroinflammatory events in autism, neurobiological markers in ASD, cytokines levels and EEG changes in ASD Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Poster Presentation Topic: Innate Immunity Citation: Inga Jácome MC (2015). CYTOKINE PROFILE, EEG AND CLINICAL PARAMETERS IN AUTISM SPECTRUM DISORDERS. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00030 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 May 2015; Published Online: 14 Sep 2015. * Correspondence: MD. Martha C Inga Jácome, Medical Doctor, Inmunology, Quito, Pichincha, Ecuador, marthytuamiga@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Martha C Inga Jácome Google Martha C Inga Jácome Google Scholar Martha C Inga Jácome PubMed Martha C Inga Jácome Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.