Abstract
ObjectiveThe aim of this study was to assess & compare the changes in cytokine levels in GCF samples of patients wearing clear aligners. MethodsGCF samples of 10 patients undergoing orthodontic treatment, for correction of lower anterior crowding with clear aligners, were collected on day 0, 1, 3, 7 and 21 using periopaper strips. The upper arch was taken as the control site. The samples collected were further analyzed using commercially available ELISA based kits. ResultsThe mean levels of IL-1β at day 0, 1, 3, 7 and 21 were compared between experimental and control sites using unpaired t-test and it was found that the levels of IL-1β were significantly elevated on experimental site in comparison to control site. ConclusionIt was concluded from the study that elevation in levels of IL-1β as a biomarker of orthodontic tooth movement reaches its peak after 24 h of force application. The clear aligners, as an alternative to conventional fixed orthodontic treatment, were found to be efficient in correcting mild to moderate lower arch crowding.
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