Abstract
This study was undertaken to assess whether gamma-linolenic acid (GLA) in the form of evening primrose oil (EPO) could affect rat serum cytokines, interferon-γ (IFN-γ), monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-α (TNF-α). The following diets were administered: control, glucan, Freund's adjuvant and glucan plus Freund's adjuvant with and without GLA. In the presence of GLA, the IFN-γ and MCP-1 levels were significantly decreased in contrast to the control group of TNF-α, which was significantly stimulated. On account of interaction between diets and GLA, the remaining diet groups of TNF-α were either not affected or were inhibited in the presence of GLA. The observations indicate that GLA may modulate the level of serum IFN-γ, MCP-1 and TNF-α, which may be a worthwhile line of treatment in certain human diseases.
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