Abstract
Immunotherapy is an important method in cancer therapy. Cytokines are signaling molecules produced by the immune system that play a crucial role in regulating immune responses. They can be harnessed in immunotherapy to modulate the immune system's activity to treat various diseases, including cancer and autoimmune disorders. It has been confirmed that Interleukin-12 (IL-12) family cytokines play an important role in tumor immune regulation. Different cytokines in the IL-12 family have different effects and regulatory roles. The IL-12 family of cytokines has shown promise in cancer immunotherapy due to its ability to activate immune responses against tumor cells. This family includes several key cytokines, such as IL-12, Interleukin-23 (IL-23), Interleukin-27 (IL-27), and Interleukin-35 (IL-35), etc., each with distinct roles in modulating the immune system and potential applications in cancer treatment. In this review, I presented the biological functions of several types of cytokines from the IL-12 family and summarized their potential in cancer treatment.
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