Abstract
Severe thermal injury leads to hypermetabolism and catabolism, and massive release of cytokines has been implicated in this hypermetabolic response. Because the cytokine response to traumatic stimuli is a highly regulated process, determination of the expression pattern of cytokine release following major burn may allow identification of a window of opportunity for modulation of cytokine expression. Before modulation can be attempted, changes in the inflammatory response as monitored by cytokine profiling must be determined following severe burn. The aim of the present study was to compare cytokine expression profiles from severely burned patients to those from normal, non-infected, non-burned children. Nineteen pediatric patients with ≥40% of TBSA burned (mean age 9 ± 1 yrs and mean time from burn to admission 5±1 days) and 14 non-burned, non-infected, normal children (mean age was 6±1 yrs) were studied. Patients with an inhalation injury or identified sepsis were excluded. Blood was collected at...
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