Abstract
Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored. We studied the inflammatory cytokine expression patterns among children with both viral-bacterial infections. Nasopharyngeal aspirate (NPA) samples were taken from children, aged < 1 year, positive for Rhinovirus, Bordetella pertussis and for Rhinovirus and Bordetella pertussis. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Our results show that co-infections display a different inflammatory pattern compared to single infections, suggesting that a chronic inflammation caused by one of the two pathogens could be the trigger for exacerbation in co-infections.
Highlights
Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored
In order to identify potential inflammatory mediators displaying a different pattern of expression in the different group of infected patients, we evaluated a panel of 40 inflammatory molecules (Fig. 1A) in 6 control samples, and in Nasopharyngeal aspirate (NPA) from 13 children positive for RV; 11 children positive for Bordetella pertussis (Bp); 16 children positive for both Bp + RV
Our findings demonstrated that Bp and RV co-infection is clinically indistinguishable from Bp infection alone, with the exception of a higher use of antibiotics before admission
Summary
Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored. In order to gain additional insights into pathogenic mechanisms, we performed a study aimed at describing and comparing the clinical patterns and nasopharyngeal cytokine profiles in children < 12 months old with single or mixed Bp and RV infections.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
