Abstract
Abstract The concentrations of interleukin-8 (IL-8) in the culture medium of seven human liver tumor cell lines in the absence or presence of cytokines were measured by enzyme-linked immunosorbent assay. IL-8 was detected in all cultures even in the absence of cytokines, and the concentrations ranged from 270 pg/ml to 62 ng/ml. The IL-8 production was stimulated by the addition of IL-1β or TNF-α into the cultures of all cell lines, while IFN-α and IFN-γ suppressed the production in some of the tumor cell lines. IL-8, which was originally described as a chemotactic factor for neutrophils and T lymphocytes, was recently reported to have a strong angiogenic potential. Therefore, IL-8 production by liver tumor cells is thought to be necessary for their vascularization. Inhibition of IL-8 production by cytokines may have therapeutic potential by suppressing neo-vascularization.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
