Abstract
ince the discovery of the PhiladelS phia chromosome in chronic myelocytic leukemia (CML) in 1960, the chromosomal analysis of leukemic cells has come to be one of the most important clinical examinations in the diagnosis of childhood leukemias and the assessment of prognosis. Almost all chromosomal abnormalities of clinical importance in leukemias has been discovered by the middle of the 1980. It is clear that there is a close relationship of chromosomal abnormalities with morphological classification in acute myeloblastic leukemias (AML), and with immunological phenotype in acute lymphoblastic leukemias (ALL). No chromosomal change specific to Hodgkin's disease (HD) has yet been recognized, perhaps because mitotic cells are difficult to obtain from the biopsled lymph nodes in HD. No chromosomal abnormality specific to childhood non-Hodgkin's lymphoma (NHL) has been also observed. Because, h igh incidenc of the lymphoblastic lymphoma (LBL) and Burkitt s lymphoma (BL) among the childhood NHL has been recognized, the incidences of chromosomal
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