Abstract
his study was conducted with the aim to extract and purify a polyphenolic compound “Resveratrol” from black grapes skin Vitis vinifera cultivated in Iraq. The pure extracted resveratrol has been employed for a cytogenetic evaluation on the normal human blood lymphocytes and revealed that the substance reduced significantly the mitotic action of the mutagen (PHA). The results of the cytogenetic study suggested that the substance appeared to have potent antimitotic and antiblastic cell formation.
Highlights
Resveratrol (3,5,4– trihydroxystilbene) belongs to a class of polyphenolic compound called stilbene
Cytogenetic Study on normal Lymphocyte Blood Cell Mitotic Index (M.I.%) The results of pure extracted resveratrol in concentrations [50,100, 150] μg/ml on the mitotic index of normal lymphocyte exposed to mitogenic action of PHA in comparison with the negative control group and positive control was shown in Table (1)
Grape skin extracted at doses (5mg/mouse) up to (100 mg/mouse) caused no increase in the cell division (MI%) of the normal mouse bone marrow cells administrated with the grape skin extract only
Summary
Resveratrol (3,5,4– trihydroxystilbene) belongs to a class of polyphenolic compound called stilbene. Preparation and purification of the extracted pure resveratrol from the grape skin.
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