Abstract
This study was established to investigate the cytogenetic effects of magnevist on mice bone marrow before and after methotrexate (MTX) 2.5 mg/kg. The negative control group was treated with 0.2 ml distilled water. Magnevist was given alone to the mice intraperitoneally with 0.6 mg/kg for 24 hrs and 48 hrs. Similarly, MTX was only intravenously injected with 2.5 mg/kg for 24 hrs and 48 hrs, which were considered as positive controls. Moreover, different combinations of magnevist/ MTX were given in terms of different time points of treatment. Results showed high induction (p<0.05) of chromosomal aberrations (CAs) and micronuclei (MN) and reduction in mitotic index (MI) of following treatments: magnevist, MTX and magnevist/MTX combination, compared to corresponding control groups. Interestingly, the combination magnevist and MTX treatment demonstrated higher induction in all biological end points than other groups. We concluded that the high combination effects may belong to increase in the aggressiveness of MTX that enhanced by magnevist and vice versa.
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