Abstract
An attempt was made to study the genotoxic effects of Ochratoxin A (OTA) and endosulfan, alone and in combination by in vivo micronuclei (MN) and chromosomal aberration (CA) assays in bone marrow cells. OTA (4 mg/kg feed) and endosulfan (5 mg/kg body weight) were administered orally, alone and in combination, to male Wistar rats daily for 30 days. Significantly higher MN frequencies and decreased ratios of polychromatic to normochromatic erythrocytes (indicator of cytotoxicity), were recorded in individual or combined treatment of OTA and endosulfan as compared with the control. Chromosomal aberrations such as gaps, isochromatid gaps, breaks and fragments were recorded in the bone marrow cells. The percent frequencies of aberrant cells were significantly higher in all the treated groups as compared to the control. The severity of genotoxic effects was more in the combination treatment group, suggesting an additive or less than additive interaction of OTA and endosulfan in rats.
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