Cytogenetic effects of albendazole on stem cells mice bone marrow

Abstract

This experiment was estimated percentage of chromosomal aberration (CAs), micronucleus` (MN) and mitotic index (MI) in bone marrow cells of mie laboratory as a way to measure/e Albendazole (ABZ) ability of the above variables. This study divided according to times injection and concentration of ABZ (200 and 400 mg / kg). Mice were divided into three groups included negative control I&II ( I no treated & II treated with 0.2 ml of normal saline), positive control split into two groups (one of them injected with ABZ 200 mg / kg, second with 400 mg / kg for 24 hours) and treatment groups. These groups are dividing to the sixth category according to concentration and period of treatment. Groups I&II (I the mouse were treated with ABZ three days 200 mg/kg for every day and II same period, but dose400mg/kg). Groups III&IV (III the mouse treated with two injection of ABZ 200 mg/kg first dose at zero day, and the second at seventh day and IV same period but dose 400mg/kg). Groups V&VI (V the mouse treated with two doses ABZ 200 mg/kg first three days, with one dose/one day and after seven days repeat three doses one dose /one days and VI same period, but the dose is 400mg/kg). The results showed that the ABZ drug led to significant increase in CA, MN and decrease in MI at (p<0.05). This percentage increases in conjunction with the length of the treatment period.