Abstract
The aim of the present study was to investigate the peculiarities of cytogenetic alterations in asthmatic patients with different phenotypes. The frequencies of chromosomal aberrations (CA) and sister-chromatid exchanges (SCE) in peripheral blood lymphocytes were investigated for 65 (32 allergic and 33 non-allergic) asthmatic patients. The control group consisted of 20 healthy subjects. The significant (p 0.05). Irrespective of the disease phenotype both CA and SCE levels were significantly higher in patients with asthma exacerbation than in stable ones. The data obtained suggest that increased levels of cytogenetic alterations in lymphocytes of asthmatic patients depend on the asthma phenotype.
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